Cooperations

LACoP

The objective of LACOP is the production of food plants with a reduced content of the allergenic storage proteins 2S albumin Bra j 1 (mustard) and 7S globulin Ara h 1 (peanut). Only the allergenic epitopes are removed from the corresponding genes by genome editing.

The advantage of CRISPR-Cas9 based genome editing is that several mutations can be introduced simultaneously at different sites in the genome. This is important because many allergenic proteins have a polygenic background. Genomically edited plants have been used in the USA, Japan, Brazil and other countries.

Persons and institutions involved in the project:

• Dr. Thomas Reinard (Koordinator)
• Prof. Dr. Jens Boch
• Prof. Dr. Traud Winkelmann
  • Leibniz Universität Hannover, Institut für Gartenbauliche Produktionssysteme
• Prof. Dr. Michael Hust
  • Technische Universität Braunschweig, Institut für Biochemie, Biotechnologie undBioinformatik, Abt. Biotechnologie
• Prof. Dr. Kirsten Beyer
  • Charité Universitätsmedizin Berlin, Klinik für Pädiatrie m.S. Pneumologie und Immunologie
• Dr. Laila Al-Halabi-Frenzel
  • DST Diagnostische Systeme und Technologien
• Sabine Schnadt
  • Deutscher Allergie- und Asthmabund e.V.