Nico Dissmeyer: Conditional Protein Function via N-Degron Pathway Mediated Proteostasis in Stress Physiology

Prof. Dr. Nico Dissmeyer

Universität Osnabrück
Pflanzenphysiologie

<link www.biologie.uni-osnabrueck.de/forschung/mikrobiologie/mitarbeiterinnen_mitarbeiter.html - "c-link c-link--extern">https://www.biologie.uni-osnabrueck.de</link>

The seminar will take place in presence at 11:45

in the <link info.cafm.uni-hannover.de/room/4107.000.009 - "c-link c-link--extern">Kirchenkanzlei</link>

Conditional Protein Function via N-Degron Pathway Mediated Proteostasis in Stress Physiology

ETHYLENE INSENSITIVE 2 (EIN2) and RESISTANCE TO DESICCATION 21A (RD21A) are novel putative degradation targets of the N-degron pathway, formerly known as the so-called N-end rule pathway (Dissmeyer, Annu Rev Plant Biol 2019). Transmembrane signal transducer EIN2 is a key element of hormone signaling; cysteine protease RD21A of response to pathogen attack and water deprivation; both also regulate senescence and cell death. The N-degron pathway may relate stability of proteins to the biochemical features of its amino (N)-terminus and its modifications (Dissmeyer et al New Phytol 2018, Dissmeyer et al Trends Biochem Sci 2017). Recent discoveries of our and other’s lab highlight diverse roles in plant response to environmental stress and in development, namely in cell proliferation and during organ growth (Dong et al. Genes Dev 2017) during plant submergence and under hypoxia (White et al Nature Comms 2017) and possibly in autophagy (Havé et al J Exp Bot 2017).

If the N-degron pathway is impaired, plant life is adversely influenced: both biotic and abiotic stress  responses like in plant-pathogen/herbivore interaction or under high ambient temperature are negatively  affected. We showed that the N-degron pathway is involved in degradation of important regulatory proteins, have developed tools for protein stability surveillance and to study N-degron pathway enzymes (E3 ligases, etc., Mot et al New Phytol 2018), substrate candidates (Naumann et al Meth Mol Biol 2016, Reichman et al Meth Mol Biol 2017) and protein expression “on demand” as genetic tool for biotechnological applications (Faden et al Nature Comms 2016). We want to understand molecular functions and biological roles of the N-degron pathway by characterizing enzymatic components and physiological substrates and develop biotechnological tools based on targeted proteolysis.

Das Plant Science Colloquium dient dem regelmäßigen Wissensaustausch im Bereich Pflanzenwissenschaften. Nationale und internationale Sprecher berichten auf dieser Plattform über hochaktuelle Forschungsergebnisse und Methoden. Die Vorträge werden auf Englisch gehalten.

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